Arylesterase activity of paraoxonase 1 in patients with primary hypertension

Abstract Introduction Paraoxonase 1 is an enzyme associated with high-density lipoprotein fraction and considered to present antioxidant activity. Objectives The aim of the study was assess arylesterase activity paraoxonase (PON1) in serum patients hypertension, due effect therapy before treatment. Patients Methods. conducted 76 primary hypertension 28 volunteers for control group. Hypertensive subjects were assigned one three groups: well controlled (n=25), poorly (n=26), newly diagnosed (n=25) hypertension. We evaluated metabolic parameters all participants using routine laboratory methods, as PON1. Results four groups differed PON1 highest levels found lowest diagnosed. All presented negative correlations between systolic diastolic blood pressure. Conclusions Effective treatment could result increased activity, despite unfavorable homocysteine concentrations blood. Untreated might decrease PON.